Research activities in my laboratory include studies of comparative fish physiology and aquatic toxicology. Within comparative physiology, a particular area of interest is osmoregulation in freshwater, marine and euryhaline fish. An additional field of research is copper homeostasis in fish. Toxicity of metals to both freshwater and seawater invertebrates and fish is also at focus with special emphasis on physiological mechanisms of metal toxicity. The above research areas are pursued through whole animal studies, biochemical and electrophysiological studies on isolated tissues and organs as well as molecular techniques. Surgical procedures and isotopic techniques are employed.
Niyogi, S., Brix, K.V. & Grosell,M. (2014): Investigation into the mechanism of chronic nickel toxicity to the freshwater pulmonate snail, Lymnaea stagnalis. Aq.Tox. 150, 36-44.
Esbaugh, A.J& Grosell, M. (2014): Esophageal desalination is mediated by Na+, H+ exchanger-2 in the gulf toadfish (Opsanus beta).Comp.Biochem.Physiol. A 171, 57-63.
Incardona, J.P., Gardner, L.D., Linbo, T.L., Swarts, T.L., Esbaugh, A.J., Mager, E.M., Stieglitz, J.D., French, B.L., Labenia, J.S., Laetz, C.A., Tagal, M., Sloan, C.A., Elizur, A., Benetti, D.D., Grosell, M., Block, B.A. & Scholz, N.L. (2014): Deepwater Horizon crude oil is cardiotoxic to the developing hearts of pelagic fish. Proc.Nat.Acad.Sci. 111(15), E1510-E1518.
Nys, C., Janssen, C.R., Mager, E., Esbaugh, A., Brix, K., Grosell, M., Stubblefield, W., Holtze, K., De Schamphelaere, K.A.C. (2014): Development and validation of a biotic ligand model for predicting chronic toxicity of lead (Pb) to Ceriodaphnia dubia. Env.Tox.Chem. 33 (2), 394-403.
Bucking, C., Wood, C.M. & Grosell, M. (2013): Uptake, handling, and excretion of Na+ and Cl- from the diet in vivo in freshwater and seawater-acclimated killifish, Fundulus heteroclitus, an agastric teleost. J.Exp.Biol. 216, 3925-3936.
Brix, K.V. & Grosell, M. (2013): Characterization of Na+ uptake in the endangered dessert pupfish, Cyprinodon macularis. Endangered Species Research. 1, 1-8.
Esbaugh, A., Mager, E.M., Brix, K.V., Santore, R. & Grosell, M. (2013): Implications of pH manipulation methods for metal toxicity: not all acidic environments are created equal. Aq.Tox. 130-131, 27-30.
Brix, K.V. & Grosell, M. (2013): Evaluation of pre- and post-zygotic mating barriers and hybrid fitness between Cyprinodon variegatus and Cyprinodon variegatus hubbsi (Cyprinodontiformes, Teleostei). J.Evol.Biol. 26, 854-866.
Munley, K.M., Brix, K.V., Panlilio, J. & Grosell, M. (2013): Growth inhibition in early life-stage tests predicts full life-cycle toxicity effects of lead on the freshwater pulmonate snail, Lymnaea stagnalis. Aq.Tox. 128-129, 60-66.
Wilson, J, Moreira-Silva, J., Ebanks, S., Vijayan, M., Coimbra, J. & Grosell, M. (2013): Mechanisms of transepithelial ammonia excretion and luminal alkalinization in the gut of an intestinal air-breathing fish, the weatherloach. J.Exp.Biol. 216, 623-632.
Brix, K.V., Wood, C.M. & Grosell, M. (2013): Measuring Titratable Alkalinity By Single Versus Double Endpoint Titration: An Evaluation in Two Cyprinodont Species and Implications for Characterizing Net H+ Flux in Aquatic Organisms. Comp.Biochem.Physiol. 164A, 221-228
Heuer, R., Esbaugh, A. & Grosell, M. (2012): Ocean acidification leads to counterproductive intestinal base loss in the gulf toadfish (Opsanus beta). Physiol.Biochem.Zool. 85(5), 450-459.
Esbaugh, A., Heuer, R. & Grosell, M. (2012): Impacts of ocean acidification on respiratory gas exchange and acid-base balance in a marine teleost, Opsanus beta. J.Comp.Physiol. 182(7), 921-934.
Woosley, R.J., Millero, F.J. & Grosell, M. (2012): The solubility of fish produced high magnesium calcite in seawater. J.Geophysical Res. 117, C04018.
Brix, K.V., Gillette, P., Capo, T.R., Pourmand, A. & Grosell, M. (2012): The Effects of Dietary Silver on Larval Growth in the Echinoderm, Lytechinus variegatus. Arch.Envirn.Contam.Tox. 63, 95-100.
Bucking, C., Wood, C.M. & Grosell, M. (2012): Diet influences salinity preference of estuarine fish. J.Exp.Biol. 215, 1965-1974.
Brix, K.V. & Grosell, M. (2012): Comparative characterization of Na+ transport in Cyprinidon variegatus variegatus and Cyprindon variegatus hubbsi: a model species complex for studying teleost invasion of freshwater. J.Exp.Biol. 215, 1199-1209.
Esbaugh, A., Brix, K.V., Mager, E.M., De Schamphelaere, K. & Grosell, M. (2012): Multilinear regression analysis, preliminary biotic ligand modeling, and cross species comparison of the effect of water chemistry on chronic lead toxicity in invertebrates. Comp.Biochem.Physiol. 155(2), 423-431.
Gilmour, K.M., Perry, S.F., Esbaugh, A., Genz, J., Taylor, J.R. & Grosell, M. (2012): Compensatory acid-base balance during salinity transfer in rainbow trout (Oncorhynchus mykiss). J.Comp.Physiol. 182(2), 259-274.
Brix, K.V., Esbaugh, A. & Grosell, M. (2012): Investigations into the Mechanism of Lead Toxicity to the Freshwater Pulmonate Snail, Lymnaea stagnalis. Aquat.Tox. 106-107, 147-156.
Wood, C.M. & Grosell, M. (2012): Independence of water fluxes from paracellular permeability in the intestine of Fundulus heteroclitus, a euryhaline teleost. J.Exp.Biol. 215, 508-517.
Secor, S.M., Taylor, J.R. & Grosell, M. (2012): Selected regulation of gastrointestinal acid-base secretion and tissue metabolism for the diamondback water snake and Burmese python. J.Exp.Biol. 215, 185-196.
Books and Book chapters
Larsen,E.H., Deaton, L.E., Onken, H., O’Donnell, M., Grosell, M., Dantzler, W.H. and Weihrauch, D. (2014): Osmoregulation and excretion. In Comprehensive Physiology, Edited by Jim Hicks and Tobias Wang. PP 405-573.
Grosell, M. (2014): Intestinal transport. In Physiology of Fishes, Edited by David Evans, James Claiborne & Suzie Currie. PP 175-205.