Center Investigator
Department of Chemistry and Biochemistry
University of Arkansas
Fayetteville, AR 72701
Phone: 479-575-6933
Fax:479-575-5178
Web Site http://www.uark.edu/depts/cheminfo/uarkchem/facultystaff/faculty/gawley/index.html
Email: bgawley@uark.edu
Biography
Education
| B.S. | (1970) | Chemistry, Stetson University, Deland Florida |
| Ph.D. | (1975) | Organic Chemistry, Duke University, Durham, North Carolina |
| Research Associate | (1975-77) | Peptide Chemistry University of North Carolina, Chapel Hill |
Research Interests
My group has two broad focus areas: synthetic and mechanistic organic chemistry, and chemical aspects of marine toxins, including isolation and characterization, SAR, sensing, and chemical modification through semisynthesis. In the area of marine toxins, we are focusing on the following projects:Develop fluorescent sensors for marine toxins using molecular recognition concepts and combinatorial chemistry
Isolate, purify, and characterize new toxins from cyanobacteria
Recent Publication
“Chemosensors for the Marine Toxin Saxitoxin” R. E. Gawley, S. Pinet; C. M. Cardona; P. K. Datta; T. Ren; W. C. Guida; J. Nydick; R. M. Leblanc, J. Am. Chem. Soc. 2002, 124, 13448-13453. This paper was featured in the web magazine ‘The Alchemist’ (http://www.chemweb.com/alchem/articles/1035208189509.html), in Nature (http://www.nature.com/nsu/021111/021111-4.html), and Trends in Analytical Chemistry (2003, 22(1), iv).
“Are Pfiesteria Species Toxicogenic? Evidence Against Production of Polyketides, Non-ribosomal Peptides, or any Ichthyotoxins by Pfiesteria shumwayae” J. P. Berry; K. S. Reece; K. S. Rein; D. G. Baden; L. W. Haas; W. Ribeiro; J. D. Shields; W. K. Vogelbein; R. E. Gawley, Proc. Nat. Acad. Sci. 2002, 99, 10970-10975. This paper was featured in or on CNN, Associated Press, Reuters, Science, New Scientist, Science News, C&ENews, the New York Times.
“Coumaryl crown ether based chemosensors for saxitoxin in water. Selective detection in the presence of sodium and potassium ions”, P. Kele; J. Orbulescu; T. L. Calhoun; R. E. Gawley; R. M. Leblanc Tetrahedron Lett. 2002, 43, 4413-4416.
“Langmuir Monolayer and Langmuir-Blodgett Film Studies of an Amphiphilic Coumaryl Crown Ether”, P. Kele; J. Orbulescu, T. L. Calhoun, R. E. Gawley, R. M. Leblanc, Langmuir 2002, 18, 8523-8526.
"Bioactive Metabolites from a Lyngbya Species Isolated from Periphyton
of the Florida Everglades", J. P. Berry, M. Gantar, R. E. Gawley,
and K. S. Rein, Proceedings of the Xth International Conference on
Harmful Algal Blooms, 2003, in press.