Center Investigator
NIEHS-MFBSC
4600 Rickenbacker Cswy
Marine Biology and Fisheries
Rosenstiel School of Marine and Atmospheric Science
Miami. FL 33149
Phone: +44-(0)20-7848-4436
Fax: +44-(0)20-7848-4500
Web Site http://www.rsmas.miami.edu http://www.kcl.ac.uk/ip/christerhogstrand/hoghome/
Biography
Education
| B.S. | (1985) | Biology, University of Göteborg, Sweden |
| Ph. D. | (1970) | Animal Physiology, Univeristy of Göteborg, Sweden |
| Postdoc | (1991) | Dept of Zoophysiology, Göteborg, Sweden |
| Postdoc | (1992-94 | Metal Physiology, Department of Biology, McMaster University, Ontario |
Research Interests
My present and continuous research is an integrated program focused on the biology and toxicology of minerals in fish. The emphasis is divided equally between basic research and issues of metal toxicology, deficiency, and environmental concerns. The basic component addresses unifying principles of how metals and other minerals are regulated in eukaryote organisms and also how metals, such as zinc, control biological processes. These studies include identification, function, and regulation of transporters and metal binding proteins as well as their genes. The more applied investigations include studies of effects of toxic metals on biochemical and physiological processes. I am also interested in development of biological markers and sensors for assessment of metal exposure and effects thereof on wild fish populations. The benefit of running these two programs in parallel is that they have reciprocal positive feedbacks on each other. Methods, ideas, and baseline values that are generated in the fundamental branch are used to drive the applied program. Within the applied research, on the other hand, pharmacological effects frequently reveal fundamental biological processes. The approaches used range from field investigations and physiological whole animal methods to protein chemistry, molecular techniques, and functional genomics and bioinformatics.Recent Publications
Hogstrand C, Balesaria S. and Glover C.N. (2002) Application of genomics and poteomics for study of the integrated response to zinc exposure in a non-model fish species, the rainbow trout. Comp. Biochem. Physiol. 133B, 523-535.
Thompson E.D., Mayer G.D., Walsh P.J., and Hogstrand C. (2002)
Sexual maturation and reproductive zinc physiology in the female squirrelfish.
J. exp. Biol. 205, 3367-3376.
Mayer G.D., Leach D.A., Kling, P., Olsson, P.-E. and Hogstrand C.
(2003) Activation of the rainbow trout metallothionein-A promoter by silver
and zinc in RTG-2 and CHSE-214 cells. Comp. Biochem. Physiol.
134B, 181-188.
Glover C.N., Balesaria S., Mayer G.D., Thompson E.D., Walsh P.J. and Hogstrand
C. (2003) Intestinal zinc uptake in the marine teleost, squirrelfish
(Holocentrus adscensionis) and Gulf toadfish (Opsanus beta).
Physiol. Biochem. Zool. (in press).
Glover C.N., Bury N.R., and Hogstrand C. (2003) Zinc uptake across
the apical membrane of freshwater rainbow trout intestine is mediated
by high-affinity, low affinity, and histidine-facilitated pathways. Biochim.
Biophys. Acta. (in press)