| Kathleen
Rein Center Investigator Department of Chemistry Florida International University University Park Miami, Florida 33199 Phone: 305-348-6682 Fax: 305-348-3772 Email:reink@fiu.edu |
Biography
Education
| B. S. | (1981) | Chemistry, University of Central Florida, Orlando, Florida |
| M. S. | (1983) | Industrial Chemistry, University of Central Florida, Orlando, Florida |
| Ph.D. | (1991) | Organic Chemistry, University of Miami, Miami, Florida |
| Post Doc | (1992-1994) | Pharmacology, University of Miami School, Miami, FL |
Honors and Professional Activities
| 1987-1990 | Maytag Fellow |
| Phi Lambda Upsilon, Beta Nu Chapter (Chemical Honor Society, University of Miami) |
Research Interests
Isolation and identification of secondary metabolites from marine microalgae. These include primarily cyanobacteria from both marine and freshwater environments and dinoflagellates from marine environments. Many of these compounds are toxic and human exposures represent a threat to public health. In addition, we are studying the biosynthesis of polyketide toxins at the genomic level. Synthesis of analogs of marine toxins.
Recent Publications
Snyder, Richard V.; Guerrero, Maria A.; Sinigalliano, Christopher D.; Winshell, Jamie; Perez, Roberto; Lopez, Jose V.; Rein, Kathleen S. (2005), “Localization of polyketide synthase encoding genes to the toxic dinoflagellate Karenia brevis”. Phytochemistry 66(15), 1767-1780.
Song, Weihua; Teshiba, Terri; Rein, Kathleen; O'Shea, Kevin E. (2005), “Ultrasonically Induced Degradation and Detoxification of Microcystin-LR (Cyanobacterial Toxin).” Environmental Science and Technology 39(16), 6300-6305.
Rodriguez, J.; Carcache, L. M.; Rein, K. S. (2005) “Residues that influence ligand selectivity in non-NMDA receptors are identified by low-mode docking search.” J. Mol. Recognit. 18:183-189.
Berry, J. P.; Gantar, M.; Gawley, R. E.; Wang, M.; Rein, K. S. (2004) “Pharmacology and Toxicology of Pahayokolide A, a Bioactive Metabolite from a Freshwater Species of Lyngbya Isolated from the Florida Everglades.” Comp. Biochem. Phys. Prt C., 139: 231-238.
Benson, J. M.; Hutt, J. A.; Rein, K. S.; Boggs, S. E.; Barr, E. B.; Fleming, L. E. (2005). “The Toxicity of Microcystin LR in Mice Following Seven Days of Inhalation Exposure.” Toxicon, 45: 691-698.
Di, W.; Rein, K. S. (2004) “Aza analogs of kainoids by dipolar cycloaddition” Tetrahedron Lett. 45: 4703-4705.
