Prof. Michael S. Schmale
RSMAS/MBF
University of Miami
4600 Rickenbacker Causeway
Miami, FL 33149
Telephone: 305.421.4140
Fax: 305.421.4600
mschmale@rsmas.miami.edu

My primary research interests are in the development and study of marine animal models of disease processes, with an emphasis on cancer. Ongoing research includes a combination of laboratory and field studies to investigate the causative agents, distribution and mechanisms of carcinogenesis of naturally occurring, transmissible tumors in one species of fish on South Florida reefs. These tumors involve the peripheral nervous system and pigment cells of the bicolor damselfish. A variety of techniques including molecular biology, virology, tissue culture, experimental manipulations of tumors in vivo, electron microscopy and immunocytochemistry are being used to determine mechanisms responsible for transformation of cells to a cancerous phenotype and for transmission of tumors.

Research is also underway in my laboratory to develop and apply techniques for transgenic manipulations of fish and invertebrates. These studies are presently focused on using the zebrafish as a model for studies of gene therapy. Other research interests include immune responses in fishes and behavioral ecology of fishes.